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Abstract

A new, simple, rapid and novel spectrophotometric method has been developed for simultaneous estimation of Atorvastatin and Telmisartan For this, simultaneous equation method is used. The method involved measurement of absorbance at two wavelengths, 246.20 nm and 290 nm, _ max of Atorvastatin and Telmisartan respectively. Beer's law obeyed in concentration range of 5-30 μg/ mL and 5-30 μg/ mL for Atorvastatin and Telmisartan respectively. The proposed method is recommended for routine analysis since it is rapid, simple, accurate and also sensitive and specific by no heating and no

organic solvent extraction. This paper describes the development and validation of UV spectroscopic method for Simultaneous estimation of Atorvastatin and Telmisartan in combined solid dosage form.

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Abstract

Two simple, rapid, accurate and economical analytical methods have been developed for the simultaneous estimation of Thiocolchicoside and Diclofenac potassium in combined capsule dosage form. First method is based on the determination of Q-value and Second method is based on simultaneous equation method. Thiocolchicoside has absorbance maxima at 259 nm and Diclofenac potassium has absorbance maxima at 271 nm in distilled water and phosphate. The absorption ratio (Q-value) was determined at 264 nm (Iso-absorptivity point) and 259 nm (_max of Thiocolchicoside Both the drugs obey Beer’s law in the concentration ranges employed for these methods. Both the methods were found to be simple, rapid, and accurate and can be adopted in routine analysis of drugs in formulations. The accuracy and reproducibility of the proposed method was statistically validated by recovery studies.

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